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0 0.5 1 1.5 2+ Respiratory symptoms 73% Improvement Relative Risk Case 85% c19probiotics.com Ahanchian et al. Probiotics for COVID-19 RCT Prophylaxis Favors probiotics Favors control
Ahanchian, 60 patient probiotics prophylaxis RCT: 73% fewer symptomatic cases [p=0.35] and 85% fewer cases [p=0.24] https://c19p.org/ahanchian
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Synbiotic for Prevention of SARS-Cov2 Infection in High Risk Hospital Staffs: A Randomized Controlled Trial
Ahanchian et al., Open Journal of Nursing, doi:10.4236/ojn.2021.115025
31 May 2021    Source   PDF   Share   Tweet
Small RCT 60 healthcare workers in Iran, showing lower cases with treatment but without statistical significance. Once daily oral synbiotic capsule (Lactocare®) containing 1 billion CFU L. (Lactobacillus) casei, L. rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, L. acidophilus, Bifidobacterium infantis, L. bulgaricus, and Fructooligosacharide. IRCT-20101020004976N6.
The immune effects of probiotics are strain-specific.
respiratory symptoms, 73.3% lower, RR 0.27, p = 0.35, treatment 1 of 29 (3.4%), control 4 of 31 (12.9%), NNT 11.
risk of case, 85.3% lower, RR 0.15, p = 0.24, treatment 0 of 29 (0.0%), control 3 of 31 (9.7%), NNT 10, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ahanchian et al., 31 May 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 14 authors.
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