Retrospective 200 severe condition hospitalized patients in Italy, 88 treated with probiotic Sivomixx, showing lower mortality with treatment.
Ceccarelli et al., 1/11/2021, retrospective, Italy, Europe, peer-reviewed, 14 authors.
risk of death, 64.2% lower, RR 0.36, p < 0.001, treatment 10 of 88 (11.4%), control 34 of 112 (30.4%), adjusted per study, odds ratio converted to relative risk.
risk of ICU admission, 15.2% lower, RR 0.85, p = 0.60, treatment 16 of 88 (18.2%), control 24 of 112 (21.4%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.