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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 64% Improvement Relative Risk ICU admission 15% c19probiotics.com/ceccarelli.html Favors probiotics Favors control
11 January 2021 - Late treatment study
Oral Bacteriotherapy in Patients With COVID-19: A Retrospective Cohort Study
Ceccarelli et al., Frontiers in Medicine, doi:10.3389/fnut.2020.613928 (Peer Reviewed)
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Retrospective 200 severe condition hospitalized patients in Italy, 88 treated with probiotic Sivomixx, showing lower mortality with treatment.
risk of death, 64.2% lower, RR 0.36, p = 0.003, treatment 10 of 88 (11.4%), control 34 of 112 (30.4%), NNT 5.3, adjusted per study, odds ratio converted to relative risk.
risk of ICU admission, 15.2% lower, RR 0.85, p = 0.60, treatment 16 of 88 (18.2%), control 24 of 112 (21.4%), NNT 31.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Ceccarelli et al., 1/11/2021, retrospective, Italy, Europe, peer-reviewed, 14 authors.
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