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0 0.5 1 1.5 2+ Mortality 64% Improvement Relative Risk ICU admission 15% c19probiotics.com Ceccarelli et al. Probiotics for COVID-19 LATE Favors probiotics Favors control
Ceccarelli, 200 patient probiotics late treatment study: 64% lower mortality [p=0.003] and 15% lower ICU admission [p=0.6] https://c19p.org/ceccarelli
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Oral Bacteriotherapy in Patients With COVID-19: A Retrospective Cohort Study
Ceccarelli et al., Frontiers in Medicine, doi:10.3389/fnut.2020.613928
11 Jan 2021    Source   PDF   Share   Tweet
Retrospective 200 severe condition hospitalized patients in Italy, 88 treated with probiotic Sivomixx, showing lower mortality with treatment.
The immune effects of probiotics are strain-specific.
risk of death, 64.2% lower, RR 0.36, p = 0.003, treatment 10 of 88 (11.4%), control 34 of 112 (30.4%), NNT 5.3, adjusted per study, odds ratio converted to relative risk.
risk of ICU admission, 15.2% lower, RR 0.85, p = 0.60, treatment 16 of 88 (18.2%), control 24 of 112 (21.4%), NNT 31.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ceccarelli et al., 1/11/2021, retrospective, Italy, Europe, peer-reviewed, 14 authors.
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