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0 0.5 1 1.5 2+ Mortality 70% Improvement Relative Risk ICU admission 82% c19probiotics.com Ceccarelli et al. Probiotics for COVID-19 LATE Favors probiotics Favors control
Ceccarelli, 69 patient probiotics late treatment study: 82% lower ICU admission [p=0.15] https://c19p.org/ceccarelli2
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Oxygen Sparing Effect of Bacteriotherapy in COVID-19
Ceccarelli et al., Nutrients, doi:10.3390/nu13082898
23 Aug 2021    Source   PDF   Share   Tweet
Prospective analysis of 69 severe COVID-19 patients requiring non-invasive oxygen therapy, 40 treated with probiotic formulation SLAB51, showing lower oxygen requirements and higher blood levels of pO2, O2Hb and SaO2 with treatment. Authors suggest that enzymes in SLAB51 could reduce oxygen requirements in intestinal cells, resulting in more oxygen available for other organs.
The immune effects of probiotics are strain-specific.
risk of death, 70.4% lower, RR 0.30, p = 0.42, treatment 0 of 40 (0.0%), control 1 of 29 (3.4%), NNT 29, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 81.9% lower, RR 0.18, p = 0.15, treatment 1 of 40 (2.5%), control 4 of 29 (13.8%), NNT 8.9.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ceccarelli et al., 8/23/2021, prospective, Italy, Europe, peer-reviewed, 10 authors.
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