Ceccarelli, 69 patient probiotics late treatment study: 82% lower ICU admission [p=0.15] https://c19p.org/ceccarelli2
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Oxygen Sparing Effect of Bacteriotherapy in COVID-19
et al., Nutrients, doi:10.3390/nu13082898
Prospective analysis of 69 severe COVID-19 patients requiring non-invasive oxygen therapy, 40 treated with probiotic formulation SLAB51, showing lower oxygen requirements and higher blood levels of pO2, O2Hb and SaO2 with treatment. Authors suggest that enzymes in SLAB51 could reduce oxygen requirements in intestinal cells, resulting in more oxygen available for other organs.The immune effects of probiotics are strain-specific.
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risk of death, 70.4% lower, RR 0.30, p = 0.42, treatment 0 of 40 (0.0%), control 1 of 29 (3.4%), NNT 29, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of ICU admission, 81.9% lower, RR 0.18, p = 0.15, treatment 1 of 40 (2.5%), control 4 of 29 (13.8%), NNT 8.9.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Ceccarelli et al., 23 Aug 2021, prospective, Italy, peer-reviewed, 10 authors.
Late treatment
is less effective
is less effective
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