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0 0.5 1 1.5 2+ Mortality 87% Improvement Relative Risk Ventilation 77% Respiratory failure 88% c19probiotics.com d'Ettorre et al. Probiotics for COVID-19 LATE Favors probiotics Favors control
d'Ettorre, 70 patient probiotics late treatment study: 87% lower mortality [p=0.14] and 88% lower progression [p=0.01] https://c19p.org/dettorre
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Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19
d'Ettorre et al., Frontiers in Medicine, doi:10.3389/fmed.2020.00389
7 Jul 2020    Source   PDF   Share   Tweet
Retrospective 70 hospitalized patients in Italy, 28 treated with probiotic Sivomixx, showing lower risk of respiratory failure and faster recovery with treatment.
The immune effects of probiotics are strain-specific.
risk of death, 87.0% lower, RR 0.13, p = 0.14, treatment 0 of 28 (0.0%), control 4 of 42 (9.5%), NNT 10, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 76.9% lower, RR 0.23, p = 0.51, treatment 0 of 28 (0.0%), control 2 of 42 (4.8%), NNT 21, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
respiratory failure, 88.4% lower, OR 0.12, p = 0.01, treatment 28, control 42, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
d'Ettorre et al., 7/7/2020, retrospective, Italy, Europe, peer-reviewed, 17 authors.
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