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0 0.5 1 1.5 2+ Case 98% Improvement Relative Risk c19probiotics.com Di Pierro et al. Probiotics for COVID-19 RCT Prophylaxis Favors probiotics Favors control
Di Pierro, 128 patient probiotics prophylaxis RCT: 98% fewer cases [p<0.0001] https://c19p.org/dipierro3
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The administration of S. salivarius K12 to children may reduce the rate of SARS-CoV-2 infection
Di Pierro et al., Minerva Medica, doi:10.23736/S0026-4806.21.07487-5
12 Mar 2021    Source   PDF   Share   Tweet
Interim report on an RCT for prophylactic treatment with S. salivarius K12, showing significantly lower cases with treatment. Only patients with symptoms or known positive contacts were tested. Trial identification/registration details are not provided.
The immune effects of probiotics are strain-specific.
risk of case, 98.0% lower, RR 0.02, p < 0.001, treatment 0 of 64 (0.0%), control 24 of 64 (37.5%), NNT 2.7, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Di Pierro et al., 12 Mar 2021, Randomized Controlled Trial, Italy, peer-reviewed, 2 authors.
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