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0 0.5 1 1.5 2+ Recovery 35% Improvement Relative Risk c19probiotics.com/gutierrezcastrellon.html Favors probiotics Favors control
24 May 2021 - Early treatment study
Probiotic improves symptomatic and viral clearance in Covid19 outpatients: a randomized, quadruple-blinded, placebo-controlled trial
Gutiérrez-Castrellón et al., Gut Microbes, doi:10.1080/19490976.2021.2018899 (preprint 5/24/2021) (Peer Reviewed)
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RCT 293 outpatients in Mexico, 147 treated with a probiotic composed of three L. plantarum strains (KABP022, KABP023 and KABP033) and one P. acidilacti strain (KABP021), showing improved recovery with treatment. There were no hospitalizations or deaths. NCT04517422.
risk of no recovery, 34.7% lower, RR 0.65, p < 0.001, treatment 69 of 147 (46.9%), control 105 of 146 (71.9%), NNT 4.0.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Gutiérrez-Castrellón et al., 5/24/2021, Double Blind Randomized Controlled Trial, placebo-controlled, Mexico, North America, peer-reviewed, 9 authors.
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