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0 0.5 1 1.5 2+ Mortality 67% Improvement Relative Risk Hospitalization 60% Hospitalization/ER/urgen.. 50% Time to resolution of sym.. 20% c19probiotics.com Haran et al. NCT04414124 Probiotics RCT EARLY TREATMENT Favors probiotics Favors control
Haran, 350 patient probiotics early treatment RCT: 50% fewer combined hospitalization/ER visits [p=0.13] and 20% faster recovery [p=0.1] https://c19p.org/haran
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Targeting the Microbiome With KB109 in Outpatients with Mild to Moderate COVID-19 Reduced Medically Attended Acute Care Visits and Improved Symptom Duration in Patients With Comorbidities
Haran et al., medRxiv, doi:10.1101/2021.03.26.21254422 (Preprint)
29 Mar 2021    Source   PDF   Share   Tweet
RCT 350 COVID+ outpatients in the USA, 174 treated with prebiotic KB109 (a microbiome metabolic therapy candidate), showing lower combined hospitalization, ER, and urgent care visits with treatment. NCT04414124.
The immune effects of probiotics are strain-specific.
risk of death, 66.5% lower, RR 0.33, p = 1.00, treatment 0 of 174 (0.0%), control 1 of 176 (0.6%), NNT 176, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), death two weeks after study withdrawal.
risk of hospitalization, 59.5% lower, RR 0.40, p = 0.45, treatment 2 of 174 (1.1%), control 5 of 176 (2.8%), NNT 59, including treatment period.
risk of hospitalization/ER/urgent care, 50.0% lower, RR 0.50, p = 0.13, treatment 7 of 169 (4.1%), control 15 of 181 (8.3%), NNT 24.
time to resolution of symptoms, 20.3% lower, relative time 0.80, p = 0.10, treatment 169, control 172.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Haran et al., 3/29/2021, Randomized Controlled Trial, USA, North America, preprint, 6 authors, study period 2 July, 2020 - 23 December, 2020, trial NCT04414124.
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