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0 0.5 1 1.5 2+ Mortality -2% Improvement Relative Risk Ventilation 18% ICU admission 27% Recovery time 5% c19probiotics.com Ivashkin et al. NCT04854941 Probiotics RCT LATE TREATMENT Favors probiotics Favors control
Ivashkin, 200 patient probiotics late treatment RCT: 2% higher mortality [p=1], 18% lower ventilation [p=1], 27% lower ICU admission [p=0.77], and 5% faster recovery [p=0.47] https://c19p.org/ivashkin
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Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial
Ivashkin et al., Probiotics Antimicrob Proteins, doi:10.1007/s12602-021-09858-5, NCT04854941 (history)
13 Oct 2021    Source   PDF   Share   Tweet
RCT 200 patients, 99 treated with a probiotic (Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301). There was no significant difference in mortality or recovery time, however benefits were seen for diarrhea. NCT04854941 (history).
The immune effects of probiotics are strain-specific.
risk of death, 2.0% higher, RR 1.02, p = 1.00, treatment 4 of 99 (4.0%), control 4 of 101 (4.0%).
risk of mechanical ventilation, 18.4% lower, RR 0.82, p = 1.00, treatment 4 of 99 (4.0%), control 5 of 101 (5.0%), NNT 110.
risk of ICU admission, 27.1% lower, RR 0.73, p = 0.77, treatment 5 of 99 (5.1%), control 7 of 101 (6.9%), NNT 53.
recovery time, 4.8% lower, relative time 0.95, p = 0.47, treatment 99, control 101.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ivashkin et al., 13 Oct 2021, Randomized Controlled Trial, Russia, peer-reviewed, 11 authors, average treatment delay 8.0 days, trial NCT04854941 (history).
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Late treatment
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