Ivashkin, 200 patient probiotics late treatment RCT: 2% higher mortality [p=1], 18% lower ventilation [p=1], 27% lower ICU admission [p=0.77], and 5% faster recovery [p=0.47] https://c19p.org/ivashkin
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Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial
et al., Probiotics Antimicrob Proteins, doi:10.1007/s12602-021-09858-5
RCT 200 patients, 99 treated with a probiotic (Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301). There was no significant difference in mortality or recovery time, however benefits were seen for diarrhea. NCT04854941.The immune effects of probiotics are strain-specific.
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risk of death, 2.0% higher, RR 1.02, p = 1.00, treatment 4 of 99 (4.0%), control 4 of 101 (4.0%).
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risk of mechanical ventilation, 18.4% lower, RR 0.82, p = 1.00, treatment 4 of 99 (4.0%), control 5 of 101 (5.0%), NNT 110.
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risk of ICU admission, 27.1% lower, RR 0.73, p = 0.77, treatment 5 of 99 (5.1%), control 7 of 101 (6.9%), NNT 53.
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recovery time, 4.8% lower, relative time 0.95, p = 0.47, treatment 99, control 101.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Ivashkin et al., 10/13/2021, Randomized Controlled Trial, Russia, Europe, peer-reviewed, 11 authors, average treatment delay 8.0 days, trial NCT04854941.
Late treatment
is less effective
is less effective
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