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0 0.5 1 1.5 2+ Case 8% Improvement Relative Risk c19probiotics.com Louca et al. Probiotics for COVID-19 Prophylaxis Favors probiotics Favors control
Louca, 372,720 patient probiotics prophylaxis study: 8% fewer cases [p=0.03] https://c19p.org/loucak
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Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app
Louca et al., BMJ Nutrition, Prevention & Health, doi:10.1136/bmjnph-2021-000250 (preprint 11/30/20)
30 Nov 2020    Source   PDF   Share   Tweet
Survey analysis of dietary supplements showing probiotic usage associated with lower incidence of COVID-19. These results are for PCR+ cases only, they do not reflect potential benefits for reducing the severity of cases. A number of biases could affect the results, for example users of the app may not be representative of the general population, and people experiencing symptoms may be more likely to install and use the app.
The immune effects of probiotics are strain-specific.
risk of case, 8.5% lower, RR 0.92, p = 0.03, odds ratio converted to relative risk, United Kingdom, all adjustment model.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Louca et al., 11/30/2020, retrospective, United Kingdom, Europe, peer-reviewed, 26 authors.
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