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0 0.5 1 1.5 2+ Mortality 67% Improvement Relative Risk ICU admission 86% Hospitalization time 26% c19probiotics.com Saviano et al. Probiotics for COVID-19 RCT LATE TREATMENT Favors probiotics Favors control
Saviano, 80 patient probiotics late treatment RCT: 86% lower ICU admission [p=0.24] and 26% shorter hospitalization [p=0.52] https://c19p.org/saviano
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COVID-19 Pneumonia and Gut Inflammation: The Role of a Mix of Three Probiotic Strains in Reducing Inflammatory Markers and Need for Oxygen Support
Saviano et al., Journal of Clinical Medicine, doi:10.3390/jcm11133758
28 Jun 2022    Source   PDF   Share   Tweet
RCT 80 COVID-19 interstitial pneumonia patients in Italy, 40 treated with probiotics, showing significantly reduced gut inflammatory markers with treatment, and lower ICU admission and mortality, without statistical significance. Bifidobacterium lactis LA 304, lactobacillus salivarius LA 302, and lactobacillus acidophilus LA 201 bid for 10 days.
The immune effects of probiotics are strain-specific.
risk of death, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 40 (0.0%), control 1 of 40 (2.5%), NNT 40, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 40 (0.0%), control 3 of 40 (7.5%), NNT 13, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
hospitalization time, 26.3% lower, relative time 0.74, p = 0.52, treatment mean 14.0 (±6.0) n=40, control mean 19.0 (±10.0) n=40.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Saviano et al., 6/28/2022, Randomized Controlled Trial, Italy, peer-reviewed, mean age 59.8, 9 authors.
Contact: veronica.ojetti@policlinicogemelli.it (corresponding author), angela.saviano@policlinicogemelli.it, alessio.migneco@policlinicogemelli.it, flavia.nasella@gmail.com, francesco.franceschi@policlinicogemelli.it, annalisa.potenza@policlinicogemelli.it, claudia.tarli@policlinicogemelli.it, valentina.siciliano@policlinicogemelli.it, carminepetruzziello@live.it.
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