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0 0.5 1 1.5 2+ Moderate/severe case 33% Improvement Relative Risk Symptomatic case 38% primary Recovery time 27% Case 43% c19probiotics.com Wischmeyer et al. NCT04399252 Probiotics RCT Prophylaxis Favors probiotics Favors control
Wischmeyer, 182 patient probiotics prophylaxis RCT: 33% fewer moderate/severe cases [p=0.15], 38% fewer symptomatic cases [p=0.02], 27% faster recovery [p=0.37], and 43% fewer cases [p=0.17] https://c19p.org/wischmeyer
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Daily Lactobacillus Probiotic versus Placebo in COVID-19-Exposed Household Contacts (PROTECT-EHC): A Randomized Clinical Trial
Wischmeyer et al., medRxiv, doi:10.1101/2022.01.04.21268275 (Preprint)
5 Jan 2022    Source   PDF   Share   Tweet
RCT 182 COVID-19 exposed patients, 91 treated with daily probiotic Lactobacillus rhamnosus GG starting a median of 3 days from exposure, showing lower symptomatic COVID-19 with treatment. There were no hospitalizations or deaths. PROTECT-EHC. NCT04399252.
The immune effects of probiotics are strain-specific.
risk of moderate/severe case, 33.3% lower, RR 0.67, p = 0.15, treatment 16 of 91 (17.6%), control 24 of 91 (26.4%), NNT 11.
risk of symptomatic case, 38.5% lower, RR 0.62, p = 0.02, treatment 24 of 91 (26.4%), control 39 of 91 (42.9%), NNT 6.1, primary outcome.
recovery time, 27.3% lower, relative time 0.73, p = 0.37, treatment 91, control 91.
risk of case, 42.9% lower, RR 0.57, p = 0.17, treatment 8 of 91 (8.8%), control 14 of 91 (15.4%), NNT 15.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wischmeyer et al., 1/5/2022, Double Blind Randomized Controlled Trial, USA, North America, preprint, 21 authors, trial NCT04399252.
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