Probiotics use is associated with improved clinical outcomes among hospitalized patients with COVID-19

8/4 Late treatment study

Zhang et al., Therapeutic Advances in Gastroenterology, doi:10.1177/17562848211035670 (Peer Reviewed)
Probiotics use is associated with improved clinical outcomes among hospitalized patients with COVID-19

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Retrospective 375 patients in China, 179 treated with probiotics (Bifidobacterium, Lactobacillus, and Enterococcus), showing improved clinical outcomes with treatment.

Zhang et al., 8/4/2021, retrospective, China, Asia, peer-reviewed, 14 authors.

hospitalization time, 13.6% lower, relative time 0.86, p = 0.009, treatment 150, control 150, PSM.

time to clinical improvement, 14.3% lower, relative time 0.86, p = 0.02, treatment 150, control 150, PSM.

time to viral-, 16.7% lower, relative time 0.83, p < 0.001, treatment 150, control 150, PSM.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 6 studies All Outcomes

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