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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization time 14% Improvement Relative Risk Time to clinical impro.. 14% Time to viral- 17% c19probiotics.com/zhang3.html Favors probiotics Favors control
4 August 2021 - Late treatment study
Probiotics use is associated with improved clinical outcomes among hospitalized patients with COVID-19
Zhang et al., Therapeutic Advances in Gastroenterology, doi:10.1177/17562848211035670 (Peer Reviewed)
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Retrospective 375 patients in China, 179 treated with probiotics (Bifidobacterium, Lactobacillus, and Enterococcus), showing improved clinical outcomes with treatment.
hospitalization time, 13.6% lower, relative time 0.86, p = 0.009, treatment 150, control 150, PSM.
time to clinical improvement, 14.3% lower, relative time 0.86, p = 0.02, treatment 150, control 150, PSM.
time to viral-, 16.7% lower, relative time 0.83, p < 0.001, treatment 150, control 150, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Zhang et al., 8/4/2021, retrospective, China, Asia, peer-reviewed, 14 authors.
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