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0 0.5 1 1.5 2+ Ventilation 65% Improvement Relative Risk Antibody formation 67% c19probiotics.com Zhang et al. NCT04581018 Probiotics LATE TREATMENT Favors probiotics Favors control
Zhang, 55 patient probiotics late treatment study: 67% lower combined mortality/intubation [p=0.06] https://c19p.org/zhang5
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Gut microbiota‐derived synbiotic formula (SIM01) as a novel adjuvant therapy for COVID‐19: An open‐label pilot study
Zhang et al., Journal of Gastroenterology and Hepatology, doi:10.1111/jgh.15796
2 Mar 2022    Source   PDF   Share   Tweet
Pilot study of probiotic SIM01 with 25 consecutive COVID-19 patients in Hong Kong and 30 control patients treated by a different team during the same time period, showing improved antibody formation, reduced viral load and pro-inflammatory responses, and improvements for gut dysbiosis. SIM01 contains bifidobacteria strains, galactooligosaccharides, xylooligosaccharide, and resistant dextrin (derived from metagenomic databases of COVID-19 patients and healthy patients).
The immune effects of probiotics are strain-specific.
risk of mechanical ventilation, 64.7% lower, RR 0.35, p = 1.00, treatment 0 of 25 (0.0%), control 1 of 30 (3.3%), NNT 30, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no antibody formation, 67.3% lower, RR 0.33, p = 0.06, treatment 3 of 25 (12.0%), control 11 of 30 (36.7%), NNT 4.1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Zhang et al., 3/2/2022, retrospective, China, Asia, peer-reviewed, 12 authors, trial NCT04581018.
Contact: siewchienng@cuhk.edu.hk, fklchan@cuhk.edu.hk.
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