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0 0.5 1 1.5 2+ Time to clinical improv.. 11% Improvement Relative Risk Hospitalization time 11% Clinical improvement 83% Clinical improvement (b) 4% c19probiotics.com Shah et al. Probiotics for COVID-19 RCT LATE TREATMENT Favors probiotics Favors control
Shah, 60 patient probiotics late treatment RCT: 11% faster recovery [p=0.19] and 11% lower hospitalization [p=0.18] https://c19p.org/shah
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Potential of the Combination of a Systemic Enzyme Complex and Probiotics administration to Combat COVID-19: A Randomized Open Label Prospective Analysis
Shah et al., Advances in Clinical Toxicology, doi:10.23880/act-16000204
2 Feb 2021    Source   PDF   Share   Tweet
Small RCT 60 patients in India, 30 treated with ImmunoSEB and ProbioSEB CSC3, showing faster recovery with treatment. CTRI/2020/09/027685, CTRI/2020/08/027168.
The immune effects of probiotics are strain-specific.
time to clinical improvement, 10.8% lower, relative time 0.89, p = 0.19, treatment 30, control 30.
hospitalization time, 10.6% lower, relative time 0.89, p = 0.18, treatment 30, control 30.
risk of no clinical improvement, 83.3% lower, RR 0.17, p = 0.005, treatment 2 of 30 (6.7%), control 12 of 30 (40.0%), NNT 3.0, day 10 mid-recovery.
risk of no clinical improvement, 3.7% lower, RR 0.96, p = 1.00, treatment 26 of 30 (86.7%), control 27 of 30 (90.0%), NNT 30, day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shah et al., 2/2/2021, Randomized Controlled Trial, India, South Asia, peer-reviewed, 3 authors, this trial uses multiple treatments in the treatment arm (combined with multi-enzyme formulation) - results of individual treatments may vary.
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