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Aspirin Metformin
Bamlanivimab Molnupiravir
Bromhexine Nigella Sativa
Budesonide Nitazoxanide
Casirivimab/i.. Povidone-Iod..
Colchicine Probiotics
Conv. Plasma Proxalutamide
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Fluvoxamine Sotrovimab
Hydroxychloro.. Vitamin A
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Probiotics study #4 of 16   All Outcomes
2/2 Late treatment study
Shah et al., Advances in Clinical Toxicology, doi:10.23880/act-16000204 (Peer Reviewed)
Potential of the Combination of a Systemic Enzyme Complex and Probiotics administration to Combat COVID-19: A Randomized Open Label Prospective Analysis
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Small RCT 60 patients in India, 30 treated with ImmunoSEB and ProbioSEB CSC3, showing faster recovery with treatment. CTRI/2020/09/027685, CTRI/2020/08/027168.
Shah et al., 2/2/2021, Randomized Controlled Trial, India, South Asia, peer-reviewed, 3 authors, this trial uses multiple treatments in the treatment arm (combined with multi-enzyme formulation) - results of individual treatments may vary.
time to clinical improvement, 10.8% lower, relative time 0.89, p = 0.19, treatment 30, control 30.
hospitalization time, 10.6% lower, relative time 0.89, p = 0.18, treatment 30, control 30.
risk of no clinical improvement, 83.3% lower, RR 0.17, p = 0.005, treatment 2 of 30 (6.7%), control 12 of 30 (40.0%), day 10 mid-recovery.
risk of no clinical improvement, 3.7% lower, RR 0.96, p = 1.00, treatment 26 of 30 (86.7%), control 27 of 30 (90.0%), day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 16 studies   All Outcomes
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